G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic K63 ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13.Previous studies have associated GPS2-mediated restriction of ubiquitination with the regulation of insulin signaling, inflammatory responses and mitochondria-nuclear communication across different tissue

Test-time adaptation (TTA) aims to optimize source-pretrained model parameters to target domains using only unlabeled test data.However, traditional TTA methods often risk overfitting to the specific, localized test domains, leading to compromised generalization.Moreover, these methods generally presume static target domains, neglecting the dynamic

The article presents the adaptation process of the modified Spenn-Fisher code of co-dependence, which allows to measure the severity of co-dependency.The study was conducted on a sample of students (N=227) and cadets (N=38) of higher educational institutions.The theoretical construct of codependency as a psychosocial state, which includes an extern

Dried chilli is one of the highly traded spices globally and is well-known for its natural flavour, colour, and unique pungent taste.It is rich in nutrients and has medicinal benefits.During the dehydration and storage process, the proliferation of unwanted microorganisms in dried chilli is unavoidable.Recently, the occurrence of toxigenic fungi an

We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium 0.75m aspiration syndrome with associated lung collapse.Echocardiogram revealed features of persistent pulmonary hypertension.He was treated with compounded oral sildenafil.Oral sildenafil has proven to be effective and safe in the management of PPHN in neon