We report a case of a newborn with persistent pulmonary hypertension (PPHN) due to meconium 0.75m aspiration syndrome with associated lung collapse.Echocardiogram revealed features of persistent pulmonary hypertension.He was treated with compounded oral sildenafil.
Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension.Therefore, in situations where inhaled nitric oxide is not Peels available it may be used as an alternative therapy in PPHN.Further randomized controlled studies are needed to determine its efficacy and pharmacokinetics.